July 23, 2015

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Today in Movie Culture: 'Batman v Superman' Meets 'The Social Network,' 'Star Wars' Western Parody and More

Here are a bunch of little bites to satisfy your hunger for movie culture:

Movie Mash-Up of the Day:

Jesse Eisenberg was obviously cast as Lex Luthor because of his Mark Zuckerberg portrayal, so this mash-up of Batman v Superman: Dawn of Justice and The Social Network is obvious but necessary:

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Star Wars of the Day:

Everyone knows the Star Wars movies are heavily influenced by Westerns, but that doesn’t mean we can’t appreciate this literal Star Wars take on the Western classic The Good, the Bad and the Ugly:

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Supercut of the Day:

You’ve seen plenty of car chase supercuts, but this one is edited by Casper Christensen and as awesome as they come:

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Movie Remix of the Day:

Mad Max: Fury Road has a bunch of pull-ins, push-outs and fast-motion shots. Editor Jorge Luengo has isolated all of them:

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PSA of the Day:

Kevin Bacon is here to promote Cop Car and tell you to keep quiet and don’t text during the movie for Alamo Drafthouse locations:

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Alternate Movie Poster of the Day:

Paramount has released new minimalist poster designs for all five of the Mission: Impossible movies, ahead of the release of Mission: Impossible – Rogue Nation. Each one focuses on the installments’ biggest stunts. Below you can see Mission: Impossible – Ghost Protocol, and you can find the other four at Screen Crush.

Fake Movie of the Day:

More auteurs need to direct superhero movies. Here’s an idea of what a John Cassavetes-helmed Wonder Woman might have looked like (via Live for Films):

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Filmmaker in Focus:

Can anyone make David Lynch‘s work weirder than it already is? Editor Jacob T. Swinney seems to be trying with his montage isolating only pieces of ambience from Lynch’s films:

Film in Focus:

Now let’s focus on Michael Mann, specifically his 1981 movie Thief, and only in close-ups, care of editor Roman Holliday:

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Classic Trailer of the Day:

This Sunday is the 60th anniversary of the premiere of Charles Laughton‘s The Night of the Hunter, one of the greatest American films of all time. Watch its original trailer below.

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House To States: Don't You Dare Demand GMO Labels

A label on a bag of popcorn indicates it is a non-GMO food. House Republicans on Thursday voted in favor of a law that would block states from mandating GMO labels.

A label on a bag of popcorn indicates it is a non-GMO food. House Republicans on Thursday voted in favor of a law that would block states from mandating GMO labels. Robyn Beck/AFP/Getty Images hide caption

itoggle caption Robyn Beck/AFP/Getty Images

The argument over genetically modified food has been dominated, in recent years, by a debate over food labels — specifically, whether those labels should reveal the presence of GMOs.

The battle, until now, has gone state-by-state. California refused to pass a labeling initiative, but Maine, Connecticut, and Vermont have now passed laws in favor of GMO-labeling.

Opponents of GMO labeling, including some of the biggest food manufacturers, have turned to Congress, and this week they achieved their first notable success.

A solid majority of the House of Representatives on Thursday voted in favor of a law that would block states from mandating GMO labels.

The debate in Congress followed familiar lines. Opponents of the bill, such as Chellie Pingree, a House Democrat from Maine who is also an organic farmer, argued that it’s important for consumers to know what they are eating.

Food labels, she pointed out, already tell consumers many things. “We know how many calories are in it, thanks to the labels. We know how much vitamin C we get per serving. We know if a fish is farm-raised or wild-caught, and we want to know those things. Shouldn’t we also be able to know if the food we are buying has GMO ingredients?” she asked.

Opponents of the bill called it an infringement of the public’s right to know what’s in their food.

Congressional supporters of the bill, meanwhile, argued that mandating labels on foods containing GMOs actually is misleading, because it suggests to consumers that GMOs are somehow risky to eat — which they are not, according to the Food and Drug Administration.

“Mandatory labeling of genetically engineered products has no basis in legitimate health or safety concerns, but is a naked attempt to impose the preferences of a small segment of the populace on the rest of us,” said Republican Mike Pompeo of Kansas, the bill’s primary sponsor.

Supporters of the bill also argued that mandatory labels would raise the cost of food.

This bill now goes to the Senate, where no similar legislation has been introduced.

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New 'The Hunger Games: Mockingjay – Part 2' Trailer Shows What Blew People Away at Comic-Con

Some left The Hunger Games: Mockingjay – Part 1 wishing it had a bit more action and scale to it. If you were one of those, the first trailer for Mockingjay – Part 2 promises that you won’t have that concern this time around.

The finale to the worldwide phenomenon is blasting the brass and beating the drums and pouring on a rightful sense of epicness as Katniss Everdeen leads a battle against President Snow, a battle that surely not everyone is going to survive.

Check it out.

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The Hunger Games: Mockingjay – Part 2 hits theaters on November 20, 2015.

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What If Chemo Doesn't Help You Live Longer Or Better?

For best quality of life, many cancer patients who can't be cured might do best to forgo chemo and focus instead on pain relief and easing sleep and mood problems, a survey of caregivers suggests.
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For best quality of life, many cancer patients who can’t be cured might do best to forgo chemo and focus instead on pain relief and easing sleep and mood problems, a survey of caregivers suggests. iStockphoto hide caption

itoggle caption iStockphoto

Chemotherapy given to patients at the end of life often does more harm than good, according to a study that calls into question this common practice.

We’re not talking here about standard chemotherapy, which can be used to greatly prolong life and sometimes cure cancer. Instead, the study published online Thursday, in the medical journal JAMA Oncology, focuses on chemotherapy given to people with solid tumors who have been diagnosed with terminal disease and aren’t expected to live more than six months.

“Chemotherapy is not meant to cure people like that,” says Holly Prigerson, director of the Cornell Center for Research on End-Of-Life Care.

Even so, people with advanced cancer are sometimes given chemotherapy with the hope that it might slightly prolong their lives or to make them more comfortable.

She and her colleagues decided to see whether chemotherapy in this circumstance actually does improve a patient’s quality of life. So they talked to the patients’ caregivers and asked them how the patient fared during the final week of life.

“They assessed things like their mood, how anxious they were, their physical symptoms and their overall quality of life,” Prigerson says. Her study finds that chemotherapy often harmed these patients at the end, reducing their quality of life. And it didn’t extend their lives, either.

This was even the case for patients who had been able to keep active and felt relatively OK when this new round of chemotherapy began.

“The conventional wisdom,” Prigerson says, “is that patients and oncologists think, ‘Why not? I have nothing to lose.’ And I think the wake-up call from these data, really, is to say, ‘There are harms being done, and there is a cost to getting chemo so late.’ “

She acknowledges that some people may still opt for chemotherapy in these circumstances. But she believes patients and doctors need to better understand the pluses and minuses of treatment at the end of life.

“I think some patients would say, ‘I don’t care, I want to be on chemotherapy; it gives me something to do and it makes me feel that I’m fighting my cancer,’ ” she says. “That’s fine, if patients know that the likelihood of them benefiting from that chemotherapy is still remote, and it will probably make them feel sicker because of toxicities and side effects of the treatment.”

But doctors should not encourage that approach to cancer care, says Dr. Charles Blanke, an oncologist at the Knight Cancer Institute of the Oregon Health and Science University.

“I think this paper strongly argues that giving chemotherapy near the end of life — that is in patients with terminal cancer — should not be the default, and oncologists should have a darn good reason if they want to do so,” Blanke says.

In an editorial accompanying the research paper, Blanke and Dr. Erik Fromme, an internist and palliative care specialist at OHSU, argue that it’s time to change this accepted medical practice. They write that “equating treatment with hope is inappropriate.”

“If the doctor really doesn’t expect you to be around in six months, it’s probably better to focus your time on something that’s not chemotherapy,” Blanke tells NPR. He focuses instead on pain relief, mood issues, sleep disturbances and other problems that can affect a patient’s quality of life.

Dr. Lowell Schnipper, who heads oncology at Beth Israel Deaconess Medical Center, helped draft treatment guidelines at the American Society of Clinical Oncology. He says he’s not ready to abandon them just yet.

“I think this is a wake-up call to talk to our patients,” Schnipper says.

Patients do need to hear a doctor say that a situation is truly dire when it is, he agrees. But each patient is different, he says, and novel approaches may sometimes be worth trying even in patients like this.

Still, Schnipper says doctors haven’t spent enough considering quality-of-life issues in these circumstances.

“That is actually an important gap in our research knowledge, and this paper might actually be a step toward filling that gap,” Schnipper says.

New Medicare rules also pay doctors to take the time to discuss end-of-life issues, and oncologists say that step could help get more of these conversations started as well.

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British Cyclist Chris Froome Leads As Tour De France Enters Final Days

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NPR’s Melissa Block speaks with Andrew Hood, the European correspondent for VeloNews, for an update on the Tour de France.

Transcript

MELISSA BLOCK, HOST:

The lead rider in this year’s Tour de France had a cup of urine tossed on him during the race by a spectator shouting, doper. His teammates have been spat upon, punched and yelled at. British cyclist Amy says that upon and yelled it. British cyclist Chris Froome is dominating this year’s tour, and at the same time, he’s dogged by speculation that he must be juiced. Cycling correspondent Andrew Hood is covering the race for VeloNews. He joins me now from Saint-Jean-de-Maurienne in the French Alps. Andrew, welcome to the program.

ANDREW HOOD: Hello. Thanks for having us.

BLOCK: And Chris Froome is wearing the yellow jersey, which means he is in the lead. He’s a little bit over three minutes ahead of his closest competitor in the standings. Three days to go before the race raps up in Paris, do you think anybody can catch him?

HOOD: That does not seem to be the case right now. The Colombian climber Nairo Quintana is kind of nipping at his heels, but Froome has this tremendous power, this tremendous cadence, his style of racing that’s really hard to get any time on him – two more hard mountain stages and then the final stage in the Champs-Elysees. It’s going to take a major disaster for Froome to lose this tour.

BLOCK: Now, it does seem that Froome doesn’t have to just win this race. He also has to prove himself in the court of public opinion about whether he’s racing clean. Is there something in particular about his performance that’s drawing scrutiny, or is this just overall general distrust and disgust with cycling?

HOOD: That’s true. That’s a good point. He’s almost fighting a battle on two fronts, on the road and then after the stage when he has to answer questions from the media and from social media where there’s a whole kind of core group of very vocal people on things like Twitter that are just convinced that Chris Froome cannot do what he does clean. Part of it is the way he races. He has this explosive kind of unique style and also just kind of the hangover of the Lance Armstrong doping scandals and really doping scandals that have haunted the sport for almost 20 years.

BLOCK: I was struck by a line in a commentary in VeloNews which says the only way to avoid suspicion is not to win. And I wonder if cycling is ever going to escape that taint of doping. What would it take?

HOOD: I think it’s going to take a few more years of these credible performances, a few more years of tours without major doping scandals. Since 2008, they introduced what’s called a biological passport, and it’s the way of measuring kind of blood indicators in an athlete, seeing if they are manipulating their blood. And there hasn’t been a major scandal since, really, about 2007, 2008. We’ve had individual cases, of course. Riders are going to cheat like people cheat on taxes. But the overall (unintelligible) is a much cleaner, credible place than it’s really ever been in the sport’s history.

BLOCK: Andrew, you’ve covered every Tour de France since 1996. How is racing, for you, different without the pull of Lance Armstrong? Despite all the scandals, he did make cycling hugely popular with a mass audience for a very long time.

HOOD: Yeah. It’s been interesting. We were talking about that over the dinner table the other night. The United States Press Corps’s very small these days. I think we have two or three Americans covering the race this year, whereas back in the Lance Armstrong days, we had correspondents from all the major newspapers, all the wires, all the magazines. And now, we’re seeing that replicated almost with the boom we’re seeing in the United Kingdom with Team Sky, Bradley Wiggins winning 2012 in (unintelligible) on his way to his second win. The tour is way more international than it used to be back in the day. It was still very much of a French, Italian, Belgian affair. And now the winners are all coming from Anglo countries, from Australia, from the United States, from the U.K. It really drives the French crazy (laughter).

BLOCK: Well, Andrew, thanks for talking with us. Enjoy the rest of the tour.

HOOD: Thank you.

BLOCK: Andrew Hood is covering the tour for VeloNews. He spoke with us from Saint-Jean-de-Maurienne in the French Alps.

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Doctors Press For Action To Lower 'Unsustainable' Prices For Cancer Drugs

Skyrocketing costs for cancer drugs have triggered a backlash.

Skyrocketing costs for cancer drugs have triggered a backlash. iStockphoto hide caption

itoggle caption iStockphoto

Anyone who’s fought cancer knows that it’s not just scary, but pricey, too.

“A lot of my patients cry — they’re frustrated,” says Dr. Ayalew Tefferi, a hematologist at the Mayo Clinic. “Many of them spend their life savings on cancer drugs and end up being bankrupt.”

The average U.S. family makes $52,000 annually. Cancer drugs can easily cost a $120,000 a year. Out-of-pocket expenses for the insured can run $25,000 to $30,000 — more than half of a typical family’s income.

“These drug prices are completely unsustainable,” Tefferi says. “Pharmaceutical companies are in greed mode, and it’s sad. It’s what I call completely unregulated.”

According to a 2013 study, these steep drug prices cause about 10 to 20 percent of cancer patients to skip or compromise the prescribed treatment. Another study found that the launch price of cancer drugs, adjusted for inflation, increased by an average of $8,500 a year between 1995 and 2013.

To make the point, Tefferi recruited 117 other doctors from across the U.S. who share his concerns. Together, they agreed on seven recommendations to make cancer drugs affordable that they want the federal government to consider. The recommendations are laid out in a commentary Thursday in the journal Mayo Clinic Proceedings.

The proposals include allowing the importation of cancer drugs across the U.S. border. Drugs are cheaper in other countries, like Canada, they argue, so why not let people with cancer bring them in for personal use?

They also favor legislation that would stop drug companies from delaying access to cheaper generic versions of their drugs. Tefferi points to Gleevec, or imatinib generically, as an example. It’s used to treat chronic myelogenous leukemia and some other cancers. “That drug should have gone generic three or four years ago,” he says. “But Novartis is doing all sorts of maneuvers to prevent it.”

The doctors recommend a change that could have an even bigger effect: creating a committee to review newly approved cancer drugs and propose a fair price based on their benefits.

“There are tons of drugs [out there] that are very expensive, but they don’t work well,” Teferri says. “There needs to be a body that does a critical assessment of a drug’s value and helps determine what the price should be based on how much it really helps. It needs to be a true, honest and transparent discussion.”

The doctors also argue that Medicare should be allowed to negotiate drug prices.

Unlike private insurance, current law prohibits the government-sponsored insurance program from negotiating the cost of drugs with pharmaceutical companies. That means the government program is overcharged and pays the high prices drug companies typically set.

For its part, PhRMA, the main trade group for drug industry, wrote a response to the doctors’ commentary that said lowering drug prices would discourage innovation. The trade group also said that cancer drugs represent only one-fifth of total spending on cancer treatment.

But Leonard Saltz, an oncologist at Memorial Sloan-Kettering Cancer Center in New York, said the doctors’ proposals are on target.

“I think they, like me and many others, have a deep concern that this is a serious problem that’s interfering with access to care,” says Saltz, who co-wrote an influential New York Times editorial on cancer drug prices in 2012 that explained why Sloan-Kettering wasn’t using a new, more expensive medicine for colorectal cancer. Saltz didn’t take part in the latest commentary.

But can a group of doctors voicing their concerns in a journal article really change anything? “This is going to be a very difficult issue to resolve,” Saltz says. “No one effort will resolve it, but any effort to engage more people in the discussion and to raise awareness will be helpful.”

Saltz adds, “Congress is the organization that’s going to be able to make a difference here.”

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Doctors Press For Action To Lower 'Unsustainable' Prices For Cancer Drugs

Skyrocketing costs for cancer drugs have triggered a backlash.

Skyrocketing costs for cancer drugs have triggered a backlash. iStockphoto hide caption

itoggle caption iStockphoto

Anyone who’s fought cancer knows that it’s not just scary, but pricey, too.

“A lot of my patients cry — they’re frustrated,” says Dr. Ayalew Tefferi, a hematologist at the Mayo Clinic. “Many of them spend their life savings on cancer drugs and end up being bankrupt.”

The average U.S. family makes $52,000 annually. Cancer drugs can easily cost a $120,000 a year. Out-of-pocket expenses for the insured can run $25,000 to $30,000 — more than half of a typical family’s income.

“These drug prices are completely unsustainable,” Tefferi says. “Pharmaceutical companies are in greed mode, and it’s sad. It’s what I call completely unregulated.”

According to a 2013 study, these steep drug prices cause about 10 to 20 percent of cancer patients to skip or compromise the prescribed treatment. Another study found that the launch price of cancer drugs, adjusted for inflation, increased by an average of $8,500 a year between 1995 and 2013.

To make the point, Tefferi recruited 117 other doctors from across the U.S. who share his concerns. Together, they agreed on seven recommendations to make cancer drugs affordable that they want the federal government to consider. The recommendations are laid out in a commentary Thursday in the journal Mayo Clinic Proceedings.

The proposals include allowing the importation of cancer drugs across the U.S. border. Drugs are cheaper in other countries, like Canada, they argue, so why not let people with cancer bring them in for personal use?

They also favor legislation that would stop drug companies from delaying access to cheaper generic versions of their drugs. Tefferi points to Gleevec, or imatinib generically, as an example. It’s used to treat chronic myelogenous leukemia and some other cancers. “That drug should have gone generic three or four years ago,” he says. “But Novartis is doing all sorts of maneuvers to prevent it.”

The doctors recommend a change that could have an even bigger effect: creating a committee to review newly approved cancer drugs and propose a fair price based on their benefits.

“There are tons of drugs [out there] that are very expensive, but they don’t work well,” Teferri says. “There needs to be a body that does a critical assessment of a drug’s value and helps determine what the price should be based on how much it really helps. It needs to be a true, honest and transparent discussion.”

The doctors also argue that Medicare should be allowed to negotiate drug prices.

Unlike private insurance, current law prohibits the government-sponsored insurance program from negotiating the cost of drugs with pharmaceutical companies. That means the government program is overcharged and pays the high prices drug companies typically set.

For its part, PhRMA, the main trade group for drug industry, wrote a response to the doctors’ commentary that said lowering drug prices would discourage innovation. The trade group also said that cancer drugs represent only one-fifth of total spending on cancer treatment.

But Leonard Saltz, an oncologist at Memorial Sloan-Kettering Cancer Center in New York, said the doctors’ proposals are on target.

“I think they, like me and many others, have a deep concern that this is a serious problem that’s interfering with access to care,” says Saltz, who co-wrote an influential New York Times editorial on cancer drug prices in 2012 that explained why Sloan-Kettering wasn’t using a new, more expensive medicine for colorectal cancer. Saltz didn’t take part in the latest commentary.

But can a group of doctors voicing their concerns in a journal article really change anything? “This is going to be a very difficult issue to resolve,” Saltz says. “No one effort will resolve it, but any effort to engage more people in the discussion and to raise awareness will be helpful.”

Saltz adds, “Congress is the organization that’s going to be able to make a difference here.”

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